Senior or Principal Scientist - Bone Biology

Slough, England, gb
Company: UCB
Category: Life, Physical, and Social Science Occupations
Published on 2021-07-29 06:02:03

Make your mark for patients.

We’re here because we want to build the future and transform patients’ lives for the better.

At UCB, our people are our experiences and achievements, our passion and drive. That’s why we’re looking for talented individuals with diverse backgrounds and experiences - not just the best and brightest, but those who care about making a meaningful difference in the lives of patients. We promote an environment of diversity, openness, and respect where people can make valuable contributions.

An exciting journey lies ahead. Will you join us in pushing the boundaries of what’s possible?


To strengthen our Musculoskeletal Group , based in Slough UK , we are looking for a talented individual to fill the position of Principal Scientist .

Role overview
The successful candidate will use their expertise in Bone Biology and will have the unique opportunity to apply their scientific and project leadership skills to contribute to our Skeletal Program at UCB. In this primarily lab-based role he/she will be supporting as well as leading or co-leading various projects, target discovery and target validation approaches.

Key responsibilities

  • To lead/co-lead drug and/or target discovery projects
  • To shape/significantly input into the strategy and direction of the project
  • To work independently to identify, introduce, develop and apply the necessary techniques to achieve the goals of the project
  • To collaborate internally and externally
  • To demonstrate scientific rigor and excellence
  • To comply with Health & Safety regulations and to ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements. 
  • To comply with HTA regulations
  • Essential requirements

  • PhD in Cell Biology or related discipline and significant postdoctoral experience in either Biotech or Pharma.
  • Experienced cell biologist with strong bone/osteoblast biology expertise 
  • Demonstrated experience with in vivo models of bone diseases, including models of fracture healing 
  • In vivo/ex vivo bone analysis with microCT
  • Experience with in vitro mineralisation assays
  • Extensive experience in experimental design/execution 
  • Expertise in primary cell isolation and culture 
  • Hands-on expertise in many aspects of in vitro biology and assay development, plate-based assays, molecular and functional end-points
  • Strong understanding of /experience with translational concepts and approaches in bone/skeletal biology
  • Additional competencies

  • Project leadership experience
  • Expertise in the role of the bone-vascular axis 
  • Experience with the analysis of patient-derived tissues
  • Stem cell experience (iPSCs, MSCs)
  • Experience with immunohistochemistry and imaging techniques
  • Molecular biology skills (RNA and protein analyses)
  • Comfortable working in an agile and team-oriented matrix environment, communicating with colleagues across functions and disciplines. 
  • Focussed and goal driven 

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