Technical Specialist, Quantitative Mass Spectrometry
Rushden, England, gb Healthcare Practitioners and Technical Occupations
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Pharmaron is a premier R&D service company supporting the life sciences industry and is staffed by over 7,000 employees in North America, Europe, Japan and China.
The Rushden site is a centre of excellence for Radiolabelled Sciences incorporating both Metabolism (which includes Clinical Metabolism, Pre-clinical ADME, In vitro and DDI services, Large Molecule Metabolism, Environmental Fate and Plant Metabolism and Metabolite Identification) and Chemistry (which includes API and IMP manufacture).
The Metabolism team is Pharmaron’s global centre of excellence for drug and environmental metabolism. We partner with our clients to provide solutions in characterising a drug candidate’s ADME properties, kinetics, bioavailability and safety, as well as determining the fate of molecules in the environment and identifying the nature of residues in livestock and crops. A passionate business with a strong appetite for growth and innovation, we are proud of our achievements to date and excited for what the future brings. To continue our growth and success, we are seeking for a Technical Specialist reporting to the Analytical Services Manager. The purpose of the role is to use expertise quantitative LC-MS/MS to develop/validate and trouble shoot methods for regulated bioanalysis and other areas of the department.
Key Roles and Responsibilities :
Perform method development/validation on large and small molecules.
Provide analytical trouble shooting support across the department, as required.
Train and mentor less experienced staff in method development and operation of mass spectrometers.
Take full responsibility for the conduct of experimental work required to successfully fulfil all the requirements of a study to the timelines stated in the Study Plan.
Effectively communicate with internal stakeholders and clients regarding study progress.
Identify new technologies, which could be of significant benefit to the group, improving capability or reducing operational costs.
Lead process improvement/new service development projects in their specialist area.
Increase profile of the department externally by publishing papers/posters and participation in expert groups.
Act as Study Director, Analytical Project Manager and/or Principal Investigator on stand-alone bioanalysis studies and the Quantitative Mass Spectrometry component of studies from other areas of the department.
PhD, MSc or BSc (Hons) in Chemistry or related subject
Experience of regulated small molecule bioanalysis including method development and validation of LC-MS methods and trouble shooting in a CRO or Pharmaceutical Company.
Experienced user of quantitative Mass Spectrometers e.g. Sciex 5500 and 6500
Experienced Study Director/Analytical Project Manager in a GLP/GCP facility
Proficient in the development of sample extraction and work-up methods including use of automation platforms (e.g. Hamilton, Tecan)
Proficient in the of development and validation of quantitative LC-MS methods
Proficient in the use of relevant software e.g. Analyst and Watson
Proficient in the use of PK software e.g. WinNonLin
Project Management experience
In addition, the following experience is desirable to be successful in this role: